Purpose: Retinal vascular disease represents a major cause for vision loss in the Western
world. Recent research has shown that neuronal and vascular damage are closely related in …

Purpose: Ciliary neurotrophic factor (CNTF) is a well-characterized neurotrophic factor
currently in clinical trials for the treatment of macular telangiectasia type II. Our previous work …

Background CCN1 (also called Cyr 61) is an extracellular matrix signaling molecule that has
been implicated in neovascularization through its interactions with several endothelial …

Retinopathy of prematurity, a leading cause of visual impairment in low birth‐weight infants,
remains a crucial therapeutic challenge. Ciliary neurotrophic factor (CNTF) is a …

purpose. To characterize molecular and cellular changes induced by sustained expression
of ciliary neurotrophic factor (CNTF) in the rds mutant mouse retina. methods. Recombinant …

Purpose: Members of the ciliary neurotrophic factor (CNTF) family of cytokines have been
shown to influence neuronal differentiation during retinal development and enhance cell …

Ciliary neurotrophic factor (CNTF) has been tested in clinical trials for human retinal
degeneration due to its potent neuroprotective effects in various animal models. To decipher …

Retinal neovascularization (RNV) is a characteristic pathological finding of retinopathy of
prematurity (ROP). Cysteine-rich 61 [Cyr61, also known as CCN family member 1 (CCN1)] …

Neurons and glial cells in the retina contribute to neovascularization, or the formation of
abnormal new blood vessels, in proliferative retinopathy, a condition that can lead to vision …

Introduction Oxygen-induced retinopathy is a type of retinal pathological neovascularization
(NV) disease that leads to vision loss and translates to a significant societal cost. Anti …