Background Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses
and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many …

Mosaic chromosomal alterations (mCAs) are the clonal expansion of large somatically
acquired structural chromosomal changes present on the autosomes and sex …

Age-related clonal expansion of cells harbouring mosaic chromosomal alterations (mCAs) is
one manifestation of clonal haematopoiesis. Identifying factors that influence the generation …

Mosaic chromosomal alterations (mCAs) are common in cancers and can arise decades
before diagnosis. A quantitative understanding of the rate at which these events occur, and …

Mosaic chromosomal alterations (mCAs) are frequently observed in cancer cells and are
regarded as one of the common features of cancers. Strikingly, accumulating studies …

Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers
for a host of human diseases. Here, to gain a better understanding of mCA rates in …

Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic
single-nucleotide variants have been well characterized in the human body, the patterns …

Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …

Background Mosaic chromosomal alterations (mCAs) detected from blood-derived DNA are
large structural alterations of clonal haematopoietic origin and are associated with various …

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …