[HTML][HTML] Sex as a biological variable in preclinical modeling of blast-related traumatic brain injury

JT McCabe, LB Tucker - Frontiers in neurology, 2020 - frontiersin.org
Approaches to furthering our understanding of the bioeffects, behavioral changes, and
treatment options following exposure to blast are a worldwide priority. Of particular need is a …

Timing matters: Sex differences in inflammatory and behavioral outcomes following repetitive blast mild traumatic brain injury

BM Baskin, AF Logsdon, SJ Lee, BD Foresi… - Brain, behavior, and …, 2023 - Elsevier
Background Repetitive blast-related mild traumatic brain injury (mTBI) caused by exposure
to high explosives is increasingly common among warfighters as well as civilians. While …

[HTML][HTML] The complexity of biomechanics causing primary blast-induced traumatic brain injury: a review of potential mechanisms

A Courtney, M Courtney - Frontiers in neurology, 2015 - frontiersin.org
Primary blast-induced traumatic brain injury (bTBI) is a prevalent battlefield injury in recent
conflicts, yet biomechanical mechanisms of bTBI remain unclear. Elucidating specific …

A Multiscale Approach to Blast Neurotrauma Modeling: Part II: Methodology for Inducing Blast Injury to in vitro Models

GB Effgen, CD Hue, E Vogel III, MB Panzer… - Frontiers in …, 2012 - frontiersin.org
Due to the prominent role of improvised explosive devices (IEDs) in wounding patterns of
US war-fighters in Iraq and Afghanistan, blast injury has risen to a new level of importance …

Resilience of females to acute blood–brain barrier damage and anxiety behavior following mild blast traumatic brain injury

WB Hubbard, GV Velmurugan, EP Brown… - Acta neuropathologica …, 2022 - Springer
Low-level blast exposure can result in neurological impairment for military personnel.
Currently, there is a lack of experimental data using sex as a biological variable in …

Bridging the gap of standardized animals models for blast neurotrauma: methodology for appropriate experimental testing

PJ VandeVord, ADC Leonardi, D Ritzel - Injury Models of the Central …, 2016 - Springer
Recent military combat has heightened awareness to the complexity of blast-related
traumatic brain injuries (bTBI). Experiments using animal, cadaver, or biofidelic physical …

Validation of laboratory animal and surrogate human models in primary blast injury studies

N Chandra, A Sundaramurthy, RK Gupta - Military medicine, 2017 - academic.oup.com
Blast-induced neurotrauma has affected more than 300,000 service members. It is important
to understand the effect of single and repeated shock-blast wave exposures on the …

[HTML][HTML] Blast-induced neurotrauma models and their requirements

I Cernak - Frontiers in neurology, 2014 - frontiersin.org
Although advances are being made in identifying some of the essential mechanisms that
may lead to chronic neurological deficits after blast-exposure (s), clinical needs continue to …

Cellular mechanisms and behavioral outcomes in blast-induced neurotrauma: comparing experimental setups

ZS Bailey, WB Hubbard, PJ VandeVord - Injury Models of the Central …, 2016 - Springer
Blast-induced neurotrauma (BINT) has increased in incidence over the past decades and
can result in cognitive issues that have debilitating consequences. The exact primary and …

Blast-induced neurotrauma: surrogate use, loading mechanisms, and cellular responses

GT Desmoulin, JP Dionne - Journal of Trauma and Acute Care …, 2009 - journals.lww.com
Background: With the onset of improved protective equipment against fragmentation, blast-
induced neurotrauma has emerged as the “signature wound” of the current conflicts in the …