Background/aims: Orally administered doxycycline, a broad-spectrum antibiotic, is an
established treatment for ocular surface diseases, particularly rosacea, meibomian gland …

Background/aims: Doxycycline is a broad spectrum antibiotic that chelates metal ions and is
frequently used as part of the treatment of ocular surface diseases. Its therapeutic value has …

Purpose To review the special pharmacology of tetracycline antibiotics as anti-inflammatory
drugs for treatment of obstructive Meibomian gland disease (MGD) Methods PubMed was …

purpose. To evaluate human corneal epithelial culture supernatant and tear fluid for the
presence of activators and inhibitors of matrix metalloproteinase (MMP)-9, MMP-3, and …

Purpose: This prospective, randomized, observer-masked, parallel-group study aimed to
compare the effect of topical azithromycin and oral doxycycline on tear film thickness (TFT) …

Background. Ocular surface disease (OSD) is a multifactorial and highly frequent problem.
Inadequate or unstable tear film is the main cause, which leads to visual impairments. One …

Abstract Background Ocular rosacea (OcR) is a chronic inflammatory disease especially
affecting lid margins. Previous studies have shown that it is accompanied by increased …

Background Matrix metalloproteinases play an important role in extracellular matrix
deposition and degradation. Based on previous clinical observations of corneal perforations …

Aims: The purpose of this paper was to determine the lacrimal concentration of IL-1α and
MMP-9 in patients with active ocular rosacea before and after systemic treatment with …

Purpose Matrix metalloproteinases (MMPs) have a role in the pathogenesis of rosacea-
associated chronic blepharitis. Doxycycline is largely used as a treatment for recalcitrant …