The limitations of anticancer drugs, including poor tumor targeting and weak uptake
efficiency, are important factors affecting tumor therapy. According to characteristics of the …

Purpose To develop microchannel-based preparation of curcumin (Cur)-loaded hybrid
nanoparticles using enzyme-targeted peptides and star-shaped polycyclic lipids as carriers …

Background Matrix-metalloproteinases, which are overexpressed in many types of cancer,
can be applied to improve the bioavailability of chemotherapeutic drugs and guide …

There is increasing interest in the use of natural compounds with beneficial pharmacological
effects for managing diseases. Curcumin (CUR) is a phytochemical that is reportedly …

Background Specific targeting ability and good cell penetration are two critical requirements
of tumor-targeted delivery systems. In the present work, we developed a novel matrix …

Efficient drug loading, tumor targeting, intratumoral penetration, and cellular uptake are the
main factors affecting the effectiveness of drug delivery systems in oncotherapy. Based on …

The major challenge of curcumin (CUR) therapy is the low bioavailability in the tumor cells,
which could be solved by targeting and manipulating nanoparticles (NPs) in the drug …

Although curcumin is effective in killing cancer cells, its low water solubility and inadequate
bioavailability remain major limitations to its therapeutic application. Formulating curcumin …

Curcumin is a natural compound with various anti-cancer properties, but its poor solubility
and low bioavailability limit its clinical application. In this study, we developed a novel …

The rationale of this study was to improve the stability, cellular uptake, and evaluate the
cytotoxicity of surface modified curcumin nanoparticles (CUR NP). CUR NP were surface …