Polygenic plague resistance in the great gerbil uncovered by population sequencing

P Nilsson, M Ravinet, Y Cui, PR Berg, Y Zhang… - PNAS …, 2022 - academic.oup.com
Pathogens can elicit high selective pressure on hosts, potentially altering genetic diversity
over short evolutionary timescales. Intraspecific variation in immune response is observable …

The genome of the plague-resistant great gerbil reveals species-specific duplication of an MHCII gene

P Nilsson, MH Solbakken, BV Schmid, RJS Orr, R Lv… - bioRxiv, 2018 - biorxiv.org
Abstract Background: The great gerbil (Rhombomys opimus) is a social rodent living in
permanent, complex burrow systems distributed throughout Central Asia, where it serves as …

AFLP genome scan in the black rat (Rattus rattus) from Madagascar: detecting genetic markers undergoing plague‐mediated selection

C Tollenaere, JM Duplantier, L Rahalison… - Molecular …, 2011 - Wiley Online Library
The black rat (Rattus rattus) is the main reservoir of plague (Yersinia pestis infection) in
Madagascar's rural zones. Black rats are highly resistant to plague within the plague focus …

Beyond an AFLP genome scan towards the identification of immune genes involved in plague resistance in Rattus rattus from Madagascar

C Tollenaere, S Jacquet, S Ivanova… - Molecular …, 2013 - Wiley Online Library
Genome scans using amplified fragment length polymorphism (AFLP) markers became
popular in nonmodel species within the last 10 years, but few studies have tried to …

Resistance to plague of Mus spretus SEG/Pas mice requires the combined action of at least four genetic factors

L Chevallier, C Blanchet, J Jaubert, E Pachulec… - Genes & …, 2013 - nature.com
We have previously described SEG/Pas as the first mouse inbred strain able to survive
subcutaneous injection of virulent Yersinia pestis, the agent of plague, and we identified …

Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar

V Andrianaivoarimanana, M Rajerison, R Jambou - BMC Research Notes, 2018 - Springer
Abstract Objectives In Madagascar, plague (Yersinia pestis infection) is endemic in the
central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die …

Transit through the Flea Vector Induces a Pretransmission Innate Immunity Resistance Phenotype in Yersinia pestis

V Vadyvaloo, C Jarrett, DE Sturdevant… - PLoS …, 2010 - journals.plos.org
Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis
exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that …

Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India

JA Lewnard, JP Townsend - Proceedings of the National …, 2016 - National Acad Sciences
Immune heterogeneity in wild host populations indicates that disease-mediated selection is
common in nature. However, the underlying dynamic feedbacks involving the ecology of …

The trophic responses of two different rodent–vector–plague systems to climate change

L Xu, BV Schmid, J Liu, X Si… - Proceedings of the …, 2015 - royalsocietypublishing.org
Plague, the causative agent of three devastating pandemics in history, is currently a re-
emerging disease, probably due to climate change and other anthropogenic changes …

The Genome of the Great Gerbil Reveals Species-Specific Duplication of an MHCII Gene

P Nilsson, MH Solbakken, BV Schmid… - Genome Biology and …, 2020 - academic.oup.com
The great gerbil (Rhombomys opimus) is a social rodent living in permanent, complex
burrow systems distributed throughout Central Asia, where it serves as the main host of …