This double-blind, placebo-controlled, four-way balanced design crossover study included
hypertensive patients aged 60–85 years with mean office-measured sitting systolic blood …

Background: Irrespective of their clinical relevance, side effects cannot be considered a
negligible problem in antihypertensive therapy. The aim of this trial was to evaluate the …

The study compared valsartan/amlodipine combination with irbesartan/hydrochlorothiazide
(HCTZ) combination in very elderly hypertensives. After a 4-week placebo period, 94 …

This multicenter, randomized, double-blind, placebo-controlled study was performed to
assess the efficacy and tolerability of lercanidipine, a new dihydropyridine calcium …

To investigate the efficacy and tolerability of lercanidipine, used as monotherapy once a day,
in elderly patients with isolated systolic hypertension (ISH), 83 patients were enrolled in this …

Methods Two groups of hypertensive patients (G1: aged< 65, G2: aged> or= 65) entered an
open study conducted over 56 days. All received lercanidipine 10 mg/d (monotherapy or …

Monotherapy frequently does not cause adequate blood pressure (BP) reduction and goal
BP is not achieved. This double-blind, randomized, crossover, placebo-controlled study …

This study was conducted to compare the antihypertensive efficacy and safety of
lercanidipine with those of lacidipine and nifedipine gastrointestinal therapeutic systems in …

The blood pressure goals set for the treatment of hypertensive patients have been lowered
in recent guidelines. To reduce blood pressure levels sufficiently, combination therapies are …

This study investigated the anti-hypertensive efficacy and tolerability of once-daily losartan
potassium (50 mg titrated to 100 mg), an angiotensin II receptor antagonist, compared with …