The multidrug resistance (MDR1) gene product, P-glycoprotein (Pgp), is a 170-kDa ATP-
dependent pump that expels a variety of anticancer drugs out of malignant cells, reducing …

Accurate determination of the expression of P-glycoprotein and its encoding mRNA, MDR-1,
is key to determining the importance of this mechanism of drug resistance in the clinic. This …

The problem of tumor cell drug resistance remains a barrier to the successful treatment of
many neoplastic diseases. Problems of tumor cell heterogeneity and expression of multiple …

We describe a new strategy for quantifying mRNA by using polymerase chain reaction
(PCR) coupled with HPLC. PCR-amplified products are directly analyzed with a specific …

Expression levels of P-glycoprotein (P-gp), the transporter encoded by the human multidrug
resistance gene (MDR1), may play an important role in drug disposition. The ability to …

Acquired and intrinsic multidrug resistance is the major reason for the failure of anticancer
chemotherapy. The most important component of clinical multidrug resistance is mediated …

Significant progress has been made in elucidating the role of elevated expression of P-
glycoprotein (Pgp), the mdrl gene product, as one mechanism underlying multidrug …

We have established competitive reverse transcriptase polymerase chain reaction (RT‐
PCR) assay for the quantification of MDR1 mRNA encoding P‐glycoprotein (P‐gp) by …

Multidrug resistance (MDR), especially that associated with overexpression of MDR1 and its
product, P-glycoprotein (Pgp), is thought to play a role in the outcome of therapy for some …

Many cancers do not respond to chemotherapy on primary exposure to drugs, thus
manifesting intrinsic drug resistance. Other cancers that do initially respond subsequently …