Osteoarthritis (OA) is the most prevalent joint disease, and it is characterized by cartilage
degeneration, synovitis, and bone sclerosis, resulting in swelling, stiffness, and joint pain …

Objective Hyperactivation of innate immunity by Toll‐like receptors (TLRs) can contribute to
the development of autoinflammatory or autoimmune diseases. This study evaluated the …

Rheumatoid Arthritis (RA) is the most common chronic inflammatory autoimmune disease
involving joints. Among several pathogenic mechanisms, the impairment of homeostatic …

Obesity has always been considered a significant risk factor in osteoarthritis (OA)
progression, but the underlying mechanism of obesity-related inflammation in OA synovitis …

Introduction The TAM (tyro 3, axl, mer) kinases are key regulators of innate immunity and are
important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these …

Objective. To investigate the role of TAM receptors in rheumatoid arthritis (RA) by
determining synovial tissue TAM receptor expression, synovial fluid levels of soluble TAM …

Rheumatoid arthritis (RA) is a common chronic autoimmune joint disease characteristic of
elevated proliferation and infiltration of fibroblast-like synoviocytes (FLS). Here, we aimed to …

Objective To investigate the role of AXL, a member of the anti-inflammatory TYRO3, AXL
MER (TAM) receptor family, in arthritis. Methods KRN serum transfer arthritis was induced in …

Hyperplastic synovial fibroblasts (SFs) serve a critical role in the pathogenesis of knee
osteoarthritis (OA); however, the molecular mechanism involved in OA during synovial tissue …

Relatively low-grade inflammatory of osteoarthritic joints is characterized by synovitis and a
catabolic and proinflammatory state of the chondrocytes and plays an important role in …