[PDF][PDF] Division and adaptation to host environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelle remodeling

S Amiar, NJ Katris, L Berry, S Dass, S Duley, CS Arnold… - Cell Reports, 2020 - cell.com
Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine
lipids from both host cell scavenging and de novo synthesis to maintain parasite …

[HTML][HTML] The flexibility of Apicomplexa parasites in lipid metabolism

S Shunmugam, CS Arnold, S Dass, NJ Katris… - PLoS …, 2022 - journals.plos.org
Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies

I Coppens - Nature Reviews Microbiology, 2013 - nature.com
Apicomplexa are some of the most widespread and poorly controlled pathogens in the
world. The metabolism of lipids in these parasites, which include Plasmodium spp …

[HTML][HTML] Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii

S Ramakrishnan, MD Docampo, JI MacRae… - Journal of Biological …, 2012 - ASBMB
Apicomplexan parasites are responsible for high impact human diseases such as malaria,
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …

Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans

S Ramakrishnan, M Serricchio, B Striepen… - Progress in Lipid …, 2013 - Elsevier
Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …

[HTML][HTML] Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal …

S Amiar, JI MacRae, DL Callahan, D Dubois… - PLoS …, 2016 - journals.plos.org
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …

Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii

J Mazumdar, E H. Wilson, K Masek… - Proceedings of the …, 2006 - National Acad Sciences
Apicomplexan parasites are the cause of numerous important human diseases including
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …

[HTML][HTML] Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage

S Dass, S Shunmugam, L Berry, CS Arnold… - Nature …, 2021 - nature.com
Apicomplexa are obligate intracellular parasites responsible for major human diseases.
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …

The intracellular parasite Toxoplasma gondii depends on the synthesis of long‐chain and very long‐chain unsaturated fatty acids not supplied by the host cell

S Ramakrishnan, MD Docampo… - Molecular …, 2015 - Wiley Online Library
Apicomplexa are parasitic protozoa that cause important human diseases including malaria,
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …

Make it or take it: fatty acid metabolism of apicomplexan parasites

J Mazumdar, B Striepen - Eukaryotic cell, 2007 - Am Soc Microbiol
Lipids are essential and highly abundant components of all organisms. They serve as the
main building blocks of the membranes that surround and compartmentalize cells, as a store …