[PDF][PDF] Division and adaptation to host environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelle remodeling
Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine
lipids from both host cell scavenging and de novo synthesis to maintain parasite …
lipids from both host cell scavenging and de novo synthesis to maintain parasite …
[HTML][HTML] The flexibility of Apicomplexa parasites in lipid metabolism
Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …
Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies
I Coppens - Nature Reviews Microbiology, 2013 - nature.com
Apicomplexa are some of the most widespread and poorly controlled pathogens in the
world. The metabolism of lipids in these parasites, which include Plasmodium spp …
world. The metabolism of lipids in these parasites, which include Plasmodium spp …
[HTML][HTML] Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii
S Ramakrishnan, MD Docampo, JI MacRae… - Journal of Biological …, 2012 - ASBMB
Apicomplexan parasites are responsible for high impact human diseases such as malaria,
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …
Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans
S Ramakrishnan, M Serricchio, B Striepen… - Progress in Lipid …, 2013 - Elsevier
Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …
[HTML][HTML] Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal …
S Amiar, JI MacRae, DL Callahan, D Dubois… - PLoS …, 2016 - journals.plos.org
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …
Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii
J Mazumdar, E H. Wilson, K Masek… - Proceedings of the …, 2006 - National Acad Sciences
Apicomplexan parasites are the cause of numerous important human diseases including
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …
[HTML][HTML] Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
Apicomplexa are obligate intracellular parasites responsible for major human diseases.
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …
The intracellular parasite Toxoplasma gondii depends on the synthesis of long‐chain and very long‐chain unsaturated fatty acids not supplied by the host cell
S Ramakrishnan, MD Docampo… - Molecular …, 2015 - Wiley Online Library
Apicomplexa are parasitic protozoa that cause important human diseases including malaria,
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …
Make it or take it: fatty acid metabolism of apicomplexan parasites
J Mazumdar, B Striepen - Eukaryotic cell, 2007 - Am Soc Microbiol
Lipids are essential and highly abundant components of all organisms. They serve as the
main building blocks of the membranes that surround and compartmentalize cells, as a store …
main building blocks of the membranes that surround and compartmentalize cells, as a store …