It has recently been shown that mutations in BETA2/NeuroD1 are responsible for the
development of type 2 diabetes mellitus (T2DM) in Caucasians. This gene is located near …

To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type
1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects …

NeuroD/BETA2, a transcription factor of the insulin gene, also plays an important role in the
development of pancreatic beta-cells. Recently, the NeuroD/BETA2 gene has been mapped …

Mutations in the NeuroD/BETA2 gene have been shown to associate with type 2 diabetes. In
the present study, we examined mutations in the NeuroD/BETA2 gene for association with …

The BETA2/NeuroD1 gene product is a transcription factor, a member of a helix-loop-helix
(HLH) family that is specifically expressed in the endocrine pancreas. HLH and homeobox …

BETA 2/NEUROD1 is a key regulator of pancreatic islet morphogenesis and insulin gene
transcription. The BETA 2/NEUROD1 gene-locus lies on human chromosome 2q32, in a …

ABSTRACT A recent case-control study in the Japanese population has shown association
of type 1 diabetes with a guanine (G) to adenine (A) change in the nucleotide sequence …

Objective: Based on onset-age stratified analysis may be useful to determine the association
of NeuroD1-Ala45Thr variation with susceptibility to genetic heterogeneous type 2 diabetes …

A meta-analysis assessed whether the Ala45Thr polymorphism of the neurogenic
differentiation 1 (NEUROD1) gene is associated with increased risk of diabetes mellitus type …

Variation in genes necessary for normal functioning and development of β-cells, eg,
NEUROD1, which encodes a transcription factor for the insulin gene and is important in β …