Novel BRD4–NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma
K Thompson-Wicking, RW Francis, A Stirnweiss… - Oncogene, 2013 - nature.com
Nuclear protein in testis (NUT)-midline carcinoma (NMC) is a rare, aggressive disease
typically presenting with a single t (15; 19) translocation that results in the generation of a …
typically presenting with a single t (15; 19) translocation that results in the generation of a …
NSD3–NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism
NUT midline carcinoma (NMC) is an aggressive subtype of squamous cell carcinoma that
typically harbors BRD4/3–NUT fusion oncoproteins that block differentiation and maintain …
typically harbors BRD4/3–NUT fusion oncoproteins that block differentiation and maintain …
“Z4” complex member fusions in NUT carcinoma: implications for a novel oncogenic mechanism
H Shiota, JE Elya, AA Alekseyenko, PM Chou… - Molecular Cancer …, 2018 - AACR
Nuclear protein in testis (NUT) carcinoma (NC) is a rare, distinctly aggressive subtype of
squamous carcinoma defined by the presence of NUT-fusion oncogenes resulting from …
squamous carcinoma defined by the presence of NUT-fusion oncogenes resulting from …
MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma
AR Grayson, EM Walsh, MJ Cameron, J Godec… - Oncogene, 2014 - nature.com
NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that is
defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins …
defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins …
[HTML][HTML] NUT carcinoma: clinicopathologic features, molecular genetics and epigenetics
V Moreno, K Saluja, S Pina-Oviedo - Frontiers in Oncology, 2022 - frontiersin.org
Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, poorly differentiated
carcinoma occurring mostly in adolescents and young adults. This tumor usually arises from …
carcinoma occurring mostly in adolescents and young adults. This tumor usually arises from …
NUT midline carcinoma
CA French - Cancer genetics and cytogenetics, 2010 - Elsevier
NUT midline carcinoma (NMC) is a rare, aggressive human cancer, genetically defined by
rearrangements of the gene NUT (HUGO symbol: C15orf55). In the majority (∼ 75%) of …
rearrangements of the gene NUT (HUGO symbol: C15orf55). In the majority (∼ 75%) of …
[HTML][HTML] Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma—An aggressive and fatal disease
A Stirnweiss, J Oommen, RS Kotecha, UR Kees… - Oncotarget, 2017 - ncbi.nlm.nih.gov
NUT midline carcinoma (NMC) is a rare and aggressive cancer, with survival typically less
than seven months, that can arise in people of any age. Genetically, NMC is defined by the …
than seven months, that can arise in people of any age. Genetically, NMC is defined by the …
[HTML][HTML] Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation
R Wang, J You - Journal of Biological Chemistry, 2015 - ASBMB
NUT midline carcinoma (NMC) is a rare but highly aggressive cancer typically caused by the
translocation t (15; 19), which results in the formation of the BRD4-NUT fusion oncoprotein …
translocation t (15; 19), which results in the formation of the BRD4-NUT fusion oncoprotein …
[HTML][HTML] Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma
Background Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare aggressive
malignancy often occurring in the tissues of midline anatomical structures. Except for the …
malignancy often occurring in the tissues of midline anatomical structures. Except for the …
[HTML][HTML] Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma
NUT midline carcinoma (NMC) belongs to a class of highly lethal and poorly differentiated
epithelial cancers arising mainly in human midline organs. NMC is caused by the …
epithelial cancers arising mainly in human midline organs. NMC is caused by the …