Behavior of the renal kallikrein in spontaneously hypertensive rats: Influence of sexual hormones and aldosterone-sensitive distal nephron ion channels

PJ Azurmendi, AR Toro, AF Celía, D Guevara… - Peptides, 2023 - Elsevier
The renal kallikrein-kinin system (RKKS) has been related to blood pressure control and
sodium and water balance. We have previously shown that female spontaneously …

Gonadectomy influences blood pressure through the kallikrein-kinin system

PJ Azurmendi, EM Oddo, LF Obika… - Kidney and Blood …, 2009 - karger.com
The kallikrein-kinin system (KKS) appears to be involved in blood pressure regulation. We
showed that ovariectomy (oVx) stimulates urinary kallikrein activity (UKa). So, we test …

Urinary Kallikrein and Blood Pressure–Gender-Different Response to Potassium Supplementation in SHR: Role of Aldosterone

EM Oddo, V De Luca Sarobe, R Krmar, RS Martín… - Nephron …, 2008 - karger.com
Aims: To test whether blood pressure is affected by potassium supplementation which
modifies urinary kallikrein (UK) in SHR of either sex, and to elucidate the mechanisms …

Renal expression of two rat kallikrein genes under diabetic conditions

C Tschöpe, M Yu, A Reinecke, T Csikos… - Journal of …, 1997 - journals.lww.com
Objective We have reported that bradykinin (BK) excretion is increased in severely diabetic
rats, independent of the activity of the main renal kininforming enzyme, true kallikrein (KLK) …

Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse

L Waeckel, L Potier, C Chollet, C Taveau… - …, 2012 - academic.oup.com
Tissue kallikrein (TK) is synthesized in arteries and distal renal tubule, the main target of
aldosterone. Urinary kallikrein excretion increases in hyperaldosteronism. We tested the …

Regulation of renal rK1-kallikrein in spontaneously hypertensive rats

D Goud, NB Oza, A Mitsialis, NG Levinsky - Kidney and Blood Pressure …, 1993 - karger.com
Urinary and renal rK1-kallikrein was studied in spontaneously hypertensive rats (SHR) and
their normotensive controls (WKY). It was demonstrated that the antiserum used for kallikrein …

The renal kallikrein-kinin system in spontaneously hypertensive rats

G Bönner, T Unger, W Rascher, G Speck, D Ganten… - Agents and Actions, 1984 - Springer
In male spontaneously hypertensive rats (SHRSP) of the stroke prone strain (Okamoto) and
in normotensive Wistar-Kyoto rats (WKY) urinary kallikrein excretion was investigated at …

Potassium supplement upregulates the expression of renal kallikrein and bradykinin B2receptor in SHR

L Jin, L Chao, J Chao - American Journal of Physiology …, 1999 - journals.physiology.org
High potassium intake is known to attenuate hypertension, glomerular lesion, ischemic
damage, and stroke-associated death. Our recent studies showed that expression of …

Distribution of kallikrein-binding protein mRNA in kidneys and difference between SHR and WKY rats

T Yang, Y Terada, H Nonoguchi… - American Journal …, 1994 - journals.physiology.org
We investigated kallikrein-binding protein (KBP) mRNA distribution in the kidney of Sprague-
Dawley (SD) rats, spontaneously hypertensive rats (SHR), and Wistar-Kyoto strain (WKY) …

The kallikrein‐kinin system as a regulator of cardiovascular and renal function

NE Rhaleb, XP Yang… - Comprehensive Physiology, 2011 - Wiley Online Library
Autocrine, paracrine, endocrine, and neuroendocrine hormonal systems help regulate
cardio‐vascular and renal function. Any change in the balance among these systems may …