Objective: White matter abnormalities may interfere with limbic cortical balance and lead to
chronic depressive syndromes. The authors used diffusion tensor imaging to test the …

OBJECTIVE: This study tested the hypothesis that microstructural abnormalities in white
matter areas of the brain containing frontostriatal tracts are associated with a low rate of …

Previous studies have demonstrated lower-diffusion anisotropy within white matter in late-
onset depression measured by diffusion tensor imaging, which provides information about …

Objective Geriatric depression consists of complex and heterogeneous behaviors unlikely to
be caused by a single brain lesion. However, abnormalities in specific brain structures and …

BACKGROUND: The dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex
(ACC) are critical for mood regulation. Alterations in the white matter connections of these …

OBJECTIVE: The purpose of this study was to determine whether microstructural
abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late …

Objective: To evaluate the location and the degree of white matter damage in late-life
depression using diffusion tensor imaging (DTI). Methods: Thirty-one patients with late-life …

Objective: The aim of this study was to explore the microstructural integrity of whole-brain
white matter by diffusion tensor imaging in first-episode, treatment-naive young adults with …

Objectives: To investigate the disruption of neural circuits in the frontal lobes and limbic
structures in late-life depressed patients compared with healthy controls, and to examine the …

BACKGROUND: Many recent studies have identified white matter abnormalities in late life
depression (LLD). These abnormalities include an increased volume of discrete white matter …