During chronic HIV-1 infection, continuing viral replication is associated with impaired
proliferative capacity of virus-specific CD8+ T cells and with the expansion and persistence …

Despite significant advancements in our understanding of HIV persistence and immunology,
long-term remission of HIV off antiretroviral therapy (ART) has not been achieved except in a …

Abstract 'Kick and kill'cure strategies aim to induce HIV protein expression in latently infected
cells (kick), and thus trigger their elimination by cytolytic T cells (kill). In the Research in Viral …

Anti-retroviral therapy (ART) can inhibit HIV proliferation but not achieve virus eradication
from HIV-infected individuals. Under ART-based HIV control, virus-specific CD8+ T-cell …

Virus-specific CD8+ T cells are associated with declining viremia in acute human
immunodeficiency virus (HIV) 1 infection, but do not correlate with control of viremia in …

To date, six vaccine strategies have been evaluated in clinical trials for their efficacy at
inducing protective immune responses against HIV infection. However, only the ALVAC …

Current HIV vaccines designed to stimulate CD8+ T cells have failed to induce immunologic
control upon infection. The functions of vaccine-induced HIV-specific CD8+ T cells were …

ABSTRACT HIV-1-specific cytotoxic T-lymphocytes (CTLs) with strong abilities to suppress
HIV-1 replication and recognize most circulating HIV-1 strains are candidates for effector T …

The ability of CD8+ T cells to effectively limit HIV-1 replication and block HIV-1 acquisition is
determined by the capacity to rapidly respond to HIV-1 antigens. Understanding both the …

Most HIV+ individuals require lifelong highly active antiretroviral therapy (HAART) to
suppress HIV replication, but fail to eliminate the virus in part because of residual replication …