A group of nucleic acids and oligonucleotides play various roles in the innate immune
system. They can stimulate pattern recognition receptors to activate innate immune cells …

Cancer immunotherapy has shown great potential as witnessed by an increasing number of
immuno-oncology drug approvals in the past few years. Meanwhile, the field of nucleic acid …

Tumor-associated macrophages (TAMs) have been proven to be a driving force in the
initiation, proliferation, metastasis and angiogenesis of various tumors. Specifically …

Recent decades have witnessed the revolutionary development of cancer immunotherapies,
which boost cancer‐specific immune responses for long‐term tumor regression. However …

The past decade has witnessed the blossom of two fields: nucleic acid therapeutics and
cancer immunotherapy. Unlike traditional small molecule medicines or protein biologics …

Traditional approaches to cancer vaccines elicit weak CD8+ T cell responses and have
largely failed to meet clinical expectations. This is in part due to inefficient antigen cross …

Hematological malignancies are a group of diseases characterized by clonal proliferation of
blood-forming cells. Malignant blood cells are classified as myeloid or lymphoid cells …

RNA oligonucleotides have emerged as a new class of biologicals that can silence gene
expression but also stimulate immune responses through specific pattern-recognition …

Nucleic acids hold promise as tools for engineering the immune system. However, for use in
patients, their delivery must be improved to overcome challenges in specificity and …

Although cancer immunotherapy has emerged as a novel cancer treatment modality, it still
suffers from low therapeutic efficacy in clinics due to the presence of a low number of …