The histologic appearance of atherosclerosis has been well described but its pathogenesis
is still vigorously debated. The purpose of the present study is to clarify the stimuli for smooth …

The study of the coronary arteries atherogenesis with the use of scanning and transmission
electron microscopy was performed on the material of emergency necropsies of 45 patients …

OBJECTIVES To determine the phenotypical state of smooth muscle cells during the
pathogenesis of an atherosclerotic lesion, and to determine the morphological state of the …

Most of the current concepts on morphogenesis of atherosclerosis attribute the development
of atherosclerotic lesions to the combined effects of two main cellular events: 1) activation of …

Both the progressive and the regressive arteriosclerotic changes are characterized mainly
by the reactions of the smooth muscle cellsinvolved. In cholesterol-induced lipofibrous …

Macrophage-derived foam cells are a prominent component of developing atherosclerotic
lesions. We describe an in vitro model of foam cell formation which mimics some aspects of …

The intima of the adult human aorta consists of three sublayers: a muscular layer lying next
to the media, a median hyperplastic layer and an innermost connective tissue layer …

The onset and evolution of ultrastructural changes in the cardiac valves induced by a
cholesterol-rich diet were investigated in rabbit and hamster. In both animal models, the …

The idea that cells of atherosclerotic plaque originate from smooth muscle cells (SMC) of the
medial layer of arteries has been central in most early studies of the mechanisms of …

With specimens of the human ascending aorta obtained from 10 cases ranging in age from
44 to 85, normal appearance, yellowish plaque and whitish plaque were studied electron …