As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …

Oxysterols are cholesterol metabolites generated in the liver and other peripheral tissues as
a mechanism of removing excess cholesterol. Oxysterols have a wide range of biological …

Oxysterols are oxygenated cholesterol derivatives and important regulators of cholesterol
metabolism, lipid homeostasis, the immune system, and membrane fluidity regulation …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …

Intracellular lipid accumulation, inflammatory responses, and subsequent apoptosis are the
major pathogenic events of metabolic disorders, including atherosclerosis and nonalcoholic …

Dysregulation of lipid metabolism is frequently associated with inflammatory conditions. The
mechanism of this association is still not clearly defined. Recently, we identified a nuclear …

ketocholesterol, a toxic oxidative product of oxysterol is a causative agent of several
diseases and disabilities concomitant to aging including cardiovascular diseases like …

Cholesterol oxidation products, also named oxysterols, can be formed either by cholesterol
auto-oxidation, enzymatically or both. Among these oxysterols, 7-ketocholesterol (7KC) is …

Certain oxysterols, when added to cultured cells, are potent regulators of cholesterol
homeostasis, decreasing cholesterol synthesis and uptake and increasing cholesterol efflux …