Uncovering new therapeutic targets for renal fibrosis holds promise for the treatment of
chronic kidney diseases. Bromodomain and extra-terminal (BET) protein inhibitors have …

Fibrosis is a common pathology in renal disease. Hypertensive nephropathy (HN) is one of
the most common secondary nephropathies that often progresses to severe renal fibrosis …

DNA methylation plays a pivotal role in the progression of renal fibrosis. Methyl-CpG–
binding domain protein 2 (MBD2), a protein reader of methylation, is involved in the …

Renal tubulointerstitial fibrosis is the common and final pathologic change of kidney in end-
stage renal disease. Interesting, endoplasmic reticulum (ER) stress is known to contribute to …

Chronic kidney disease (CKD) involves interstitial fibrosis as an underlying pathological
process associated with compromised renal function irrespective of etiological cause of the …

Fibrosis represents a common pathway to end-stage renal disease. Transforming growth
factor-β (TGF-β) plays a critical role in the progression of kidney fibrosis. In the present study …

Background: Oxidative stress has been identified as an important pathogenesis mechanism
in the development of renal interstitial fibrosis in unilateral ureteral obstruction (UUO) …

Renal fibrosis is the major cause of chronic kidney disease, and the Rho/Rho-associated
coiled-coil kinase (ROCK) signaling cascade is involved in the renal fibrotic processes …

Bromodomain and extra-terminal (BET) protein inhibitors have been shown to effectively
inhibit tumorgenesis and ameliorate pulmonary fibrosis by targeting bromodomain proteins …

Renal fibrosis is the culmination of processes driven by signaling pathways involving
transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear …