sulfate modified N-acetylglucosamine (6-sulfo-GlcNAc) is often found as part of many
biologically important carbohydrate epitopes such as 6-sulfo-Le X. In these epitopes, the 6 …

The β-1, 4-galactosyltransferase 7 (β4GalT7) enzyme is involved in proteoglycan synthesis.
In the presence of a manganese ion, it transfers galactose from UDP-galactose to xylose on …

In order to understand how β-(1→ 4)-galactosyltransferase recognizes its glycosyl acceptor,
substrate specificities were investigated using synthetic 2-acetamido-2-deoxy-d …

Abstract α1, 3galactosyltransferase (α1, 3GalT) catalyzes the synthesis of a range of
glycoconjugates containing the Galα1, 3Gal epitope which is recognized by the naturally …

Human β1, 4-GalT (galactosyltransferase) 7 is involved in the biosynthesis of the
tetrasaccharide linker protein region (GlcAβ1→ 3Galβ1→ 3Galβ1→ 4Xylβ1)(where GlcA is …

Studies on wild-type and mutant glycosyltransferases have shown that they can transfer
modified sugars with a versatile chemical handle, such as keto or azido group, that can be …

N-Acetyllactosamine is the most prevalent disaccharide moiety in the glycans on the surface
of mammalian cells and often found as repeat units in the linear and branched …

β-1, 4-Galactosyltransferase I (β4Gal-T1) normally transfers Gal from UDP-Gal to GlcNAc in
the presence of Mn2+ ion (Gal-T activity) and also transfers Glc from UDP-Glc to GlcNAc (Glc …

The capacity of UDP-N-acetyl-α-D-glucosamine (UDP-GlcNAc) as an in vitro acceptor
substrate for β-1, 4-galactosyltransferase (β4GalT1, EC 2.4. 1.38) from human and bovine …

Abstract Inhibitors of Galactosyltransferase (GalT) have the potential of reducing the
amounts of adhesive carbohydrates on secreted and cell surface-bound glycoproteins. We …