Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory disease.
Autoantibodies (autoAbs) against double‐stranded DNA (ds DNA), the hallmark of lupus …

The aim of the present study was to evaluate the effects of the B7/cluster of differentiation
(CD) 28 signaling pathway on experimental lupus nephritis and examine the molecular …

Systemic lupus erythematosus (SLE) is a CD4+ T cell–dependent, immune complex–
mediated, autoimmune disease that primarily affects women of childbearing age. Generation …

Objective B cell hyperactivity is a common denominator in murine and human systemic
lupus erythematosus. Some susceptibility genes in lupus are associated with B cell …

T cell receptor recognition of antigen and major histocompatibility complex (signal 1) and T
cell co‐stimulation (signal 2) are essential for full T cell activation, differentiation, and …

Teff/Treg imbalance orchestrated the onset and the progression of the lupus nephritis in a
DBA/2→ B6D2F1 murine model with cGVHD. In this paper, we first used 145-2C11 Ab to …

Autoimmunity results from a failure in central and/or peripheral tolerance; however, the
events that initiate and maintain this dysfunction remain unclear. To better understand the …

Lupus is an antibody-mediated autoimmune disease. The production of pathogenic, class
switched and affinity maturated autoantibodies in lupus is dependent on T cell help. A …

Toll-like receptors appear to play an important role in the pathogenesis of lupus-like
nephritis in mice. In human and mouse, CD180 is a homologue of TLR4. In SLE patients, the …

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder with
prevalent hypertension that significantly contributes to the mortality in this patient population …