Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients

SC Cheatham, MR Fleming, DP Healy… - International journal of …, 2013 - Elsevier
The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics
of piperacillin and tazobactam administered by prolonged infusion in obese patients …

Population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese and nonobese patients

EK Chung, SC Cheatham, MR Fleming… - The Journal of …, 2015 - Wiley Online Library
The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …

Serum piperacillin/tazobactam pharmacokinetics in a morbidly obese individual

D Newman, MH Scheetz, OA Adeyemi… - Annals of …, 2007 - journals.sagepub.com
Objective: To report pharmacokinetic alterations and optimal dosing of piperacillin/
tazobactam in an obese patient. Case Summary: A 39-year-old morbidly obese (weight 167 …

Pharmacokinetic analysis of piperacillin administered with tazobactam in critically ill, morbidly obese surgical patients

AW Sturm, N Allen, KD Rafferty, DN Fish… - … : The Journal of …, 2014 - Wiley Online Library
Study Objective To evaluate the steady‐state pharmacokinetic and pharmacodynamic
parameters of piperacillin in morbidly obese, surgical intensive care patients. Design Open …

Population pharmacokinetics of piperacillin in nonobese, obese, and morbidly obese critically ill patients

AS Alobaid, SC Wallis, P Jarrett, T Starr… - Antimicrobial agents …, 2017 - Am Soc Microbiol
The treatment of infections in critically ill obese and morbidly obese patients is challenging
because of the combined physiological changes that result from obesity and critical illness …

Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under–and …

B Jung, M Mahul, D Breilh, R Legeron… - Critical care …, 2017 - journals.lww.com
Objective: Obesity and critical illness modify pharmacokinetics of antibiotics, but piperacillin-
tazobactam continuous IV infusion pharmacokinetics has been poorly studied in obese …

Steady-state pharmacokinetics and pharmacodynamics of piperacillin/tazobactam administered by prolonged infusion in hospitalised patients

KM Shea, SC Cheatham, MF Wack, DW Smith… - International journal of …, 2009 - Elsevier
The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …

Evaluation of an alternative extended-infusion piperacillin–tazobactam dosing strategy for the treatment of gram-negative infections

EM Winstead, PD Ratliff, RP Hickson… - International journal of …, 2016 - Springer
Introduction To enhance the probability of pharmacodynamic target attainment, piperacillin–
tazobactam can be administered as either a continuous or extended-infusion dosage …

Dosing of piperacillin/tazobactam in a morbidly obese patient

H Deman, J Verhaegen, L Willems… - Journal of antimicrobial …, 2012 - academic.oup.com
Sir, The combination of piperacillin and tazobactam has been shown to be efficacious for the
treatment of intra-abdominal infections, skin and soft tissue infections, bacteraemia and …

Piperacillin-tazobactam in intensive care units: a review of population pharmacokinetic analyses

I El-Haffaf, JA Caissy, A Marsot - Clinical pharmacokinetics, 2021 - Springer
Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …