The effect of drugs that influence the opioidergic and monoaminergic neuronal systems on
the antinociceptive action of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3 …

Abstract Tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiadiazole] is able to
increase the pain threshold in the tail-flick test in mice. The effect of tizanidine was …

The antinociceptive action of tizanidine [5-chloro-(2-imidazolin-2-yl-amino)-2, 1, 3-
benzothiadiazole], a centrally acting muscle relaxant, was evaluated after subcutaneous or …

The site of action of tizanidine (5-chloro-4-(2-imidazolin-2-yl-amino) 2, 1, 3-
benzothiadiazole) was investigated in a tail-flick test in comparison with clonidine and …

The alpha-adrenoceptor agonists, clonidine and xylazine, produced a dose-dependent
antinociceptive effect in the mouse writhing assay as does morphine. Fluoxetine, a highly …

The antinociceptive, tolerance-developing and anti-withdrawal activities of tizanidine [5-
chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzo-thiadiazole] were investigated by …

The present study investigated the effects of WB4101, a selective α 1-adrenoceptor blocking
agent, and idazoxan. a selective α 2-adrenoceptor blocking agent, on antinociception and …

The present study compared the potency of a range of α-adrenoceptor agonists in producing
antinociception and sedation in the rat and dog. In the rat, the selective α 2-adrenoceptor …

The potency of adrenoceptor and cholinoceptor agents to antagonize the antinociceptive
action of xylazine, an α-sympathomimetic agent, was studied. Yohimbine (1–2 mg/kg) and …

Moxonidine is a mixed I1 imidazoline/α2-adrenergic receptor agonist structurally related to
clonidine. In the present studies, moxonidine, like clonidine, produced a dose-and time …