The plant Ophiorrhiza pumila produces camptothecin (CPT), a kind of terpene indole
alkaloid (TIAs) that has been widely used in treatment of cancer. Tryptophan-arginine-lysine …

Camptothecin (CPT) has unique anti-tumor activities, and its analogs such as irinotecan and
topotecan are clinically used as anti-cancer drugs. Recently, CPT biosynthesis pathway is …

Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …

Camptothecin (CPT) is a natural compound with remarkable antitumor activities due to its
special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to …

Uncaria rhynchophylla (Miq.) Miq. ex Havil, a traditional medicinal herb, is enriched with
several pharmacologically active terpenoid indole alkaloids (TIAs). At present, no method …

Being a good anti-tumor drug, camptothecin (CPT) is a kind of modified monoterpene indole
alkaloid firstly isolated from the deciduous Chinese happy tree with rapidly increasing …

Anoectochilus roxburghii is a rare and precious plant with medicinal and healthcare
functions. Embryo abortion caused the lack of resources. Polyamine promoted its flowering …

The WRKY gene family is a plant-specific transcription factor (TF) that regulates many
physiological processes and (a) biotic stress responses. Despite this, little is known about …

Benzylisoquinoline alkaloids (BIQ) are among the most structurally diverse and
pharmaceutically valuable secondary metabolites. A plant-specific WRKY-type transcription …