The cellular distribution of muscarinic acetylcholine receptor protein in the frontal cortex of
Alzheimer (AD) patients, age-matched and middle-aged controls was assessed …

Ligand binding studies show marked reductions of nicotinic, but not of muscarinic binding
sites in Alzheimer's disease. Using monoclonal antibodies we studied …

The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex
(area 10) of 1) Alzheimer patients and compared to 2) age-matched and 3) middle-aged …

The total population of muscarinic receptors and a subpopulation of muscarinic receptors
with high affinity for agonists were measured with [3 H] quinuclidinyl benzilate and [3 H] …

Muscarinic (cholinergic) receptor binding sites (MRB) were studied by determining the 3H-
QNB binding in four cortical areas and hippocampus of 20 histologically confirmed …

The brain systems mostly affected by Alzheimer's disease (AD) are listed in Table 1 (Rossor
et al., 1982; Bird et al., 1983; Davies, 1979). They include either neuronal populations which …

The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

Nicotinic cholinergic receptors were measured in human frontal cortex using [3 H] nicotine
and [3 H] acetylcholine (in the presence of atropine) as receptor ligands. A parallel marked …

Total muscarinic receptor levels, the levels of the subtypes exhibiting high and low affinity for
pirenzepine, and the highand lowaffinity agonist states of the receptor were investigated in …

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the
cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study,[3 …