Efficient drug loading, tumor targeting, intratumoral penetration, and cellular uptake are the
main factors affecting the effectiveness of drug delivery systems in oncotherapy. Based on …

The limitations of anticancer drugs, including poor tumor targeting and weak uptake
efficiency, are important factors affecting tumor therapy. According to characteristics of the …

Background Matrix-metalloproteinases, which are overexpressed in many types of cancer,
can be applied to improve the bioavailability of chemotherapeutic drugs and guide …

Tumor-responsive nanocarriers are highly valuable and demanded for smart anticancer
drug delivery, where a quick release of chemotherapeutic drugs in tumors is preferred …

Background Specific targeting ability and good cell penetration are two critical requirements
of tumor-targeted delivery systems. In the present work, we developed a novel matrix …

Enzyme‐responsive and biocompatible supramolecular nanocarriers (NCs) have attracted
intensive attention in the field of biomaterials, and have found many feasible applications …

Purpose To develop microchannel-based preparation of curcumin (Cur)-loaded hybrid
nanoparticles using enzyme-targeted peptides and star-shaped polycyclic lipids as carriers …

Stimuli-responsive peptide dendrimer-drug conjugates have presented significant potential
for cancer therapy. To develop an effective nanoscale chemotherapeutic prodrug, we …

Most of the nanomedicines can reduce the side effects of anti-tumor chemical drugs but do
not have good enough therapeutic efficacy, largely due to the sustained drug release profile …

Poor tumour penetration became a major challenge for the use of nanoparticles in
anticancer therapy. To further enhance the tumour penetration efficiency, we developed a …