Intracellular protein degradation is a tightly regulated process that in many cases is
controlled by protein ubiquitylation. The ubiquitin pathway is a major route by which cells not …

Proteolysis via the ubiquitin system plays important roles in a variety of basic cellular
processes. Among these are regulation of cell cycle and division, modulation of the immune …

Protein degradation is one of the tactics employed by the cell for irreversibly inactivating
proteins. In eukaryotes, ATP-dependent protein degradation in the cytoplasm and nucleus is …

A growing number of cellular functions have been shown to be regulated through protein
degradation. The selective degradation of many short-lived proteins in eukaryotic cells is …

Ubiquitination is the biochemical process in which proteins are marked by ubiquitin, a 76
amino acid protein. It occurs intracellularly in eukaryotes and regulates a wide variety of …

Ubiquitin modification of a variety of protein targets within the cell plays important roles in
many cellular processes. Among these are regulation of gene expression, regulation of cell …

Ubiquitination, a post-translational modification, regulates a vast array of fundamental
biological processes with dysregulation of the dedicated enzymes giving rise to pathologies …

In the ubiquitin system, a target substrate is modified by ubiquitin or a ubiquitin-like protein.
In most cases, proteins are modified by multiple moieties of ubiquitin, generating a …

A necessary step in the degradation ofproteins by the ubiquitin system is recognition by the
ubiquitin-protein ligases (s). Various structural features of the proteolytic substrate render# …

The ubiquitin system has two major functions in eukaryotic cells: it regulates protein
degradation, which is essential for normal cellular function and for the removal of potentially …