Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate …

DR Wakeman, DE Redmond Jr… - Stem cells …, 2014 - academic.oup.com
Transplanted multipotent human fetal neural stem cells (hfNSCs) significantly improved the
function of parkinsonian monkeys in a prior study primarily by neuroprotection, with only 3 …

Transplantation of mouse CGR8 embryonic stem cells producing GDNF and TH protects against 6-hydroxydopamine neurotoxicity in the rat

T Liu, Z Ma, Y Zhou, J Xie - The international journal of biochemistry & cell …, 2013 - Elsevier
Embryonic stem cells (ESCs)-based therapies have been increasingly recognized as a
potential tool to replace or support cells and their function damaged by the …

[HTML][HTML] Mouse embryonic stem cells expressing gdnf show enhanced dopaminergic differentiation and promote behavioral recovery after grafting in Parkinsonian rats

R Lara-Rodarte, D Cortés, K Soriano… - Frontiers in Cell and …, 2021 - frontiersin.org
Parkinson's disease (PD) is characterized by the progressive loss of midbrain dopaminergic
neurons (DaNs) of the substantia nigra pars compacta and the decrease of dopamine in the …

Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor

M Espejo, B Cutillas, E Arenas… - Cell …, 2000 - journals.sagepub.com
The transplantation of fetal mesencephalic cell suspensions into the brain striatal system is
an emerging treatment for Parkinson's disease. However, one objection to this procedure is …

Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease

MM Daadi, BA Grueter, RC Malenka, DE Redmond Jr… - PloS one, 2012 - journals.plos.org
The use of human embryonic stem cells (hESCs) to repair diseased or injured brain is
promising technology with significant humanitarian, societal and economic impact …

Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease

P Åkerud, JM Canals, EY Snyder… - Journal of …, 2001 - Soc Neuroscience
Neural stem cells (NSCs) have been proposed as tools for treating neurodegeneration
because of their capacity to give rise to cell types appropriate to the structure in which they …

Dissociation between short‐term increased graft survival and long‐term functional improvements in Parkinsonian rats overexpressing glial cell line‐derived …

B Georgievska, T Carlsson, B Lacar… - European Journal of …, 2004 - Wiley Online Library
The present study was designed to analyse whether continuous overexpression of glial cell
line‐derived neurotrophic factor (GDNF) in the striatum by a recombinant lentiviral vector …

Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment

YM Ganat, EL Calder, S Kriks… - The Journal of …, 2012 - Am Soc Clin Investig
Embryonic stem cells (ESCs) represent a promising source of midbrain dopaminergic (DA)
neurons for applications in Parkinson disease. However, ESC-based transplantation …

Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo

X Kang, H Xu, S Teng, X Zhang… - Proceedings of the …, 2014 - National Acad Sciences
Embryonic stem cell-based therapies exhibit great potential for the treatment of Parkinson's
disease (PD) because they can significantly rescue PD-like behaviors. However, whether …

Glial cell line‐derived neurotrophic factor–secreting genetically modified human bone marrow‐derived mesenchymal stem cells promote recovery in a rat model of …

A Glavaski‐Joksimovic, T Virag… - Journal of …, 2010 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive
degeneration of nigrostriatal dopaminergic (DA) neurons. The therapeutic potential of glial …