Over the past few decades, there has been a global surge in the prevalence of obesity,
rendering it a globally recognized epidemic. Contrary to simply being a medical condition …

Obesity is one of the greatest public health challenges of the 21st century. Obesity is
currently responsible for∼ 0.7–2.8% of a country's health costs worldwide. Treatment is …

The melanocortin-4 receptor (MC4R)–embedded in the leptin–melanocortin pathway–is
activated by proopiomelanocortin (POMC)-derived neuropeptides such as α-and β …

The prevalence of obesity and the associated comorbidities highlight the importance of
understanding the regulation of energy homeostasis. The central melanocortin system plays …

Neuroanatomical, genetic and pharmacological studies provide undisputable evidence for
the role of the melanocortin system in the regulation of feeding behavior and body weight. In …

Obesity is increasing in prevalence across all sectors of society, and with it a constellation of
associated ailments including hypertension, type 2 diabetes, and eating disorders. The …

Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …

Abstract The melanocortin‐4 receptor (MC4R) has been critically investigated for the past
two decades, and novel findings regarding MC4R signalling and its potential exploitation in …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

The global prevalence of obesity highlights the importance of understanding on regulation of
energy homeostasis. The central melanocortin system is an important intersection …