Alpha-Toxin of Clostridium perfringens Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens

AL Keyburn, SA Sheedy, ME Ford… - Infection and …, 2006 - Am Soc Microbiol
The Clostridium perfringens alpha-toxin has previously been implicated as the major
virulence factor in necrotic enteritis in chickens, although definitive proof has not been …

Necrotic enteritis in broilers: an updated review on the pathogenesis

L Timbermont, F Haesebrouck, R Ducatelle… - Avian …, 2011 - Taylor & Francis
Clostridium perfringens-induced necrotic enteritis and related subclinical disease have
become economically significant problems for the broiler industry. Fortunately, scientific …

[HTML][HTML] Association between avian necrotic enteritis and Clostridium perfringens strains expressing NetB toxin

AL Keyburn, XX Yan, TL Bannam… - Veterinary …, 2010 - ncbi.nlm.nih.gov
A novel toxin, NetB, has recently been identified in virulent avian Clostridium perfringens
isolates and shown to be an essential virulence factor in a clinical necrotic enteritis isolate …

Necrotic enteritis in chickens: a paradigm of enteric infection by Clostridium perfringens type A

KK Cooper, JG Songer - Anaerobe, 2009 - Elsevier
Withdrawal of antimicrobial growth promoters and ionophore coccidiostats has been
accompanied by a resurgence in incidence of necrotic enteritis (NE), a severe Clostridium …

[HTML][HTML] NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens

AL Keyburn, JD Boyce, P Vaz, TL Bannam… - PLoS …, 2008 - journals.plos.org
For over 30 years a phospholipase C enzyme called alpha-toxin was thought to be the key
virulence factor in necrotic enteritis caused by Clostridium perfringens. However, using a …

Immunization of Broiler Chickens against Clostridium perfringens-Induced Necrotic Enteritis

RR Kulkarni, VR Parreira, S Sharif… - Clinical and Vaccine …, 2007 - Am Soc Microbiol
Necrotic enteritis (NE) in broiler chickens is caused by Clostridium perfringens. Currently, no
vaccine against NE is available and immunity to NE is not well characterized. Our previous …

In vitro production of necrotic enteritis toxin B, NetB, by netB-positive and netB-negative Clostridium perfringens originating from healthy and diseased broiler chickens

L Abildgaard, TE Sondergaard, RM Engberg… - Veterinary …, 2010 - Elsevier
The Clostridium perfringens necrotic enteritis toxin B, NetB, was recently proposed as a new
key virulence factor for the development of necrotic enteritis (NE) in broilers. The aim of the …

[HTML][HTML] The successful experimental induction of necrotic enteritis in chickens by Clostridium perfringens: a critical review

B Shojadoost, AR Vince, JF Prescott - Veterinary research, 2012 - Springer
Necrotic enteritis (NE) is one of the most important enteric diseases in poultry and is a high
cost to the industry worldwide. It is caused by avian-specific, Necrotic Enteritis Beta toxin …

[HTML][HTML] Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases: a review on bovine necro-haemorrhagic enteritis

E Goossens, BR Valgaeren, B Pardon… - Veterinary …, 2017 - Springer
Bovine necro-haemorrhagic enteritis is an economically important disease caused by
Clostridium perfringens type A strains. The disease mainly affects calves under intensive …

Origin of Clostridium perfringens isolates determines the ability to induce necrotic enteritis in broilers

L Timbermont, A Lanckriet… - … and infectious diseases, 2009 - Elsevier
Since the ban on growth-promoting antibiotics in animal feed in the European Union,
necrotic enteritis has become a major cause of mortality in broiler chickens. Despite the …