Apoptosis is an important regulatory event in testicular homeostasis and optimization of
sperm production. Sertoli cells (SCs) form the blood–testis barrier creating a special …

In the mammalian testis, spermatogenesis is a highly coordinated process of germ cell
development, which ends with the release of 'mature'spermatozoa. The fine regulation of …

Although it has been well established that spermatogenic cells undergo apoptosis when
treated with ethanol, the molecular mechanisms behind it remain to be investigated. Adult …

In mammals, spontaneous apoptosis is observed particularly in differentiating
spermatogonia and in spermatocytes. 17β-Estradiol (E2) in primary rat pachytene …

This review aims at characterising the process of male germ cell death, focusing on the role
of testicular steroid hormones, the role of two important induction pathways of apoptosis, the …

A growing body of evidence demonstrates that germ cell death both spontaneous (during
normal spermatogenesis) and that induced by suppression of hormonal support or …

17β-Estradiol (E2) and Testosterone (T) exert actions in most animal tissues, in addition to
the reproductive system. Thus, both sex steroid hormones affect growth and different cell …

The aim of the present study was to investigate the intracellular signaling events
downstream of the classical estrogen receptors (ESRs) and G protein-coupled estrogen …

Apoptosis is widely known to play a major role on diseases related to male infertility.
Diseases of the male genital tract as defective spermatogenesis, decreased sperm motility …

Insulin is essential for the regulation of glucose homeostasis. Insulin dysfunction occurs in
several pathologies, such as diabetes mellitus, which is associated with fertility problems …