Salicylazosulfapyridine (SASP), a drug used in the treatment of inflammatory bowel
diseases, has been reported to depress the fertility in males. Therefore, some authors have …

Male infertility is widlely accepted as a common complication of sulphasalazine (SASP)
therapy for inflammatory bowel disease. SASP is used in the maintenance long-term …

Recently, several reports have suggested that salicylazosulfapyridine causes a reduction in
semen quality in patients with ulcerative colitis. After withdrawal of the drug pregnancies …

A male patient suffering from ulcerative colitis, presented with primary infertility due to
sulphasalazine therapy. Sulphasalazine was discontinued and the patient was treated with …

Objective To determine the (reversible) antifertility effect in the male rat of sulfasalazine, a
common therapy for inflammatory bowel disease. Methods Sulfasalazine (120, 250 and 500 …

Seminal abnormalities are a common side effect of Salazosulphapyridine (SASP) treatment.
We evaluated semen qualities and sex hormone concentrations in 11 patients with …

Our purpose was to study the effects of long‐term salazopyrine treatment on male fertility.
Seven patients, 21–37 years old, who had been treated for ulcerative colitis with 3 g/day of …

Sulfasalazine, which has been used for treatment of ulcerative colitis in man, caused a dose-
dependent and reversible reduction in fertility of the male rat. By five weeks after forced …

Several derivatives of sulfasalazine were tested for their antifertility activity in male rats. The
compounds were administered to groups of rats daily by oral gavage for 28 days. Fertility of …

Fertility parameters of 10 men with chronic inflammatory bowel disease under treatment with
sulfasalazine for at least 5 years were compared to those of 19 control subjects. Seminal …