Selective serotonin reuptake inhibitors are first-line treatment for most anxiety disorders, but
their mechanism of anxiolytic action has not been clarified. Selective serotonin reuptake …

Our previous study showed that conditioned fear stress (CFS) increased serotonin (5-HT)
metabolism in the medial prefrontal cortex and induced freezing behavior. Although these …

Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal
model of anxiety. In the present study, freezing was used to determine the anxiolytic activity …

In an attempt to clarify the role of the brain serotonergic system in the psychopathology of
anxiety, we examined the effect of a psychological stress, conditioned fear stress, on …

The effects of the co-administration of the serotonin (5-HT) 1A receptor antagonists NAN-190
or (+)-WAY100135 with a selective 5-HT reuptake inhibitor (SSRI) citalopram on conditioned …

This study investigated the effect of co-administration of the selective 5-HT1A receptor
antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 with a …

Background Though drugs binding to serotonergic 5-HT2A receptors have long been
claimed to influence human anxiety, it remains unclear if this receptor subtype is best …

Among drugs that act on serotonergic neurotransmission, selective serotonin (5-HT)
reuptake inhibitors (SSRIs) are now the gold standard for the treatment of anxiety disorders …

BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) effectively treat various
anxiety disorders, although symptoms of anxiety are often exacerbated during early stages …

The relationships between serotonin and fear and anxiety disorders have been much
studied yet many important questions remain, despite selective serotonin reuptake inhibitors …