Protein ubiquitination plays an important role in regulating the abundance and conformation
of a broad range of eukaryotic proteins. This process involves a cascade of enzymes …

The importance of the ubiquitin system largely depends on ubiquitin ligases, E3s, as they
determine the specificity of the system. Rbx1/ROC1/Hrt1, a RING finger protein, functions as …

The cullin-containing E3 ubiquitin ligases play an important role in regulating the
abundance of key proteins involved in cellular processes such as cell cycle and cytokine …

Cullin E3 ligases are the largest family of ubiquitin ligases with diverse cellular functions.
One of seven cullin proteins serves as a scaffold protein for the assembly of the multisubunit …

The class III ubiquitin conjugating enzymes (E2s) are distinguished from other E2s by the
presence of unique N-terminal domains, and the utilization of importin-11 for transport into …

The Cdc34 E2 ubiquitin (Ub) conjugating enzyme catalyzes polyubiquitination of a substrate
recruited by the Skp1-Cullin 1-F-box protein-ROC1 E3 Ub ligase. Using mutagenesis …

The Elongin BC-box protein family includes the von Hippel-Lindau tumor suppressor and
suppressor of cytokine signaling proteins, which are substrate recognition subunits of …

The cullin-containing ubiquitin-protein isopeptide ligases (E3s) play an important role in
regulating the abundance of key proteins involved in cellular processes such as cell cycle …

Cullins are members of a family of scaffold proteins that assemble multisubunit ubiquitin
ligase complexes to confer substrate specificity for the ubiquitination pathway. Cullin3 (Cul3) …

Cullin-based E3 ligases are a large family of ubiquitin ligases with diverse cellular functions.
They are composed of one of six mammalian cullin homologues, the Ring finger containing …