The chromosome of Streptomyces coelicolor A3 (2), a model organism for the genus
Streptomyces, contains a cryptic type I polyketide synthase (PKS) gene cluster which was …

Polyketides are structurally diverse secondary metabolites that include macrolides,
polyethers and aromatics. They exhibit various biological activities such as antibacterial …

In the search for Type II polyketide synthases (PKSs) a DNA fragment was isolated from
Streptomyces antibioticus ATCC 11891 (a producer of oleandomycin). DNA sequencing of …

Streptomyces coelicolor A3 (2) and Streptomyces violaceoruber Tü22 produce the
antibiotics actinorhodin and granaticin, respectively. Both the aglycone of granaticin and the …

Genome sequencing of Streptomyces coelicolor A3 (2) revealed an uncharacterized type I
polyketide synthase gene cluster (cpk). Here we describe the discovery of a novel …

Abstract Streptomyces coelicolor A3 (2) is an extensively studied model organism for the
genetic studies of Streptomycetes–a genus known for the production of a vast number of …

Streptomyces arenae produces the aromatic polyketide naphthocyclinone, which exhibits
activity against Gram-positive bacteria. A cosmid clone containing the putative …

The high G+ C content and large genome size make the sequencing and assembly of
Streptomyces genomes more difficult than for other bacteria. Many pharmaceutically …

A fragment of DNA was cloned from the Streptomyces griseus K-63 genome by using genes
(act) for the actinorhodin polyketide synthase (PKS) of Streptomyces coelicolor as a probe …

Background Recent advances in genome sequencing, combined with bioinformatic
analysis, has led to the identification of numerous novel natural product gene clusters …