It is a basic principle of genetics that each chromosome is transmitted from parent to
offspring with a probability that is given by Mendel's laws. However, several known …

Over the past century researchers have identified normal genetic variation and studied that
variation in diverse human populations to determine the amounts and distributions of that …

We develop predictions for the correlation of heterozygosity and for linkage disequilibrium
between two loci using a simple model of population structure that includes migration …

Variations in gene sequence and expression underlie much of human variability. Despite
the known biological roles of differential allelic gene expression resulting from X …

Nucleotides of the Human Genome? Page 1 Am. J. Hum. Genet. 46:649-651, 1990 Opinion:
How Can One Study Individual Variation for 3 Billion Nucleotides of the Human Genome? L …

Understanding the pattern of linkage disequilibrium (LD) in the human genome is important
both for successful implementation of disease-gene mapping approaches and for inferences …

Studies of copy-number variation and linkage disequilibrium (LD) have typically excluded
complex regions of the genome that are rich in duplications and prone to rearrangement. In …

Variation in gene expression is a fundamental aspect of human phenotypic variation.
Several recent studies have analyzed gene expression levels in populations of different …

Variation in the human genome sequence is key to understanding susceptibility to disease
in modern populations and the history of ancestral populations. Unlocking this information …

Whole-genome association studies (WGAS) bring new computational, as well as analytic,
challenges to researchers. Many existing genetic-analysis tools are not designed to handle …