Evaluation of genotoxicity in leukocytes and testis following intra-vasal contraception with RISUG and its reversal by DMSO and NaHCO3 in Wistar albino rats

AS Ansari, I Alam, M Hussain, SR Khan… - Reproductive Toxicology, 2013 - Elsevier
Evaluation of genotoxicity of RISUG®–a vas based contraceptive, was carried out in the
present study. Animals were allotted into groups of sham operated control, vas occlusion …

Safety evaluation through genotoxicity and apoptotic markers following RISUG® induced contraception and its reversal in male rabbits

AS Ansari, A Badar, NK Lohiya - Reproductive Toxicology, 2018 - Elsevier
The safety evaluation following vas occlusion with RISUG® and its reversal with DMSO and
NaHCO 3, using genotoxicity tests and apoptotic marker assays, was carried out in rabbits …

Studies on biochemical, oxidative and genotoxicity alterations following vas blockage with reversible inhibition of sperm under guidance and reversal in rats

AS Ansari, M Hussain, SR Khan, A Badar… - Indian Journal of …, 2022 - journals.lww.com
OBJECTIVE: To evaluate the biochemical and genotoxicity at the level of reactive oxygen
species (ROS) following vas occlusion with RISUG and its reversal by Dimethyl sulphoxide …

Toxicity and mutagenicity evaluation following RISUG contraception reversal in rats

AS Ansari, M Hussain, SR Khan… - International …, 2018 - journals.sagepub.com
Reestablishment of fertility, after a male contraceptive method, is of great concern. In this
context, RISUG (Reversible Inhibition of Sperm Under Guidance) has been evaluated for its …

Relative suitability of DMSO and NaHCO3 for reversal of RISUG® induced long‐term contraception

AS Ansari, M Hussain, SR Khan, NK Lohiya - Andrology, 2016 - Wiley Online Library
Among the vas‐based methods on trial, reversible inhibition of sperm under guidance
(RISUG®), a co‐polymer of styrene and maleic anhydride is being projected as an effective …

[PDF][PDF] RISUG® offers early contraception: an experience during phase III clinical trials

NK Lohiya, AS Ansari, TC Sadasukhi… - J Reprod Healthc …, 2022 - researchgate.net
Objectives: An early contraceptive efficacy with reasonable assurance of reversibility has
been a challenge in male contraception. With nearly four decades of research in reversible …

Sperm characteristics and teratology in rats following vas deferens occlusion with RISUG and its reversal

NK Lohiya, R Suthar, A Khandelwal… - … journal of andrology, 2010 - Wiley Online Library
The functional success of the reversal of vas occlusion by styrene maleic anhydride
(RISUG), using the solvent vehicle, Dimethyl Sulphoxide (DMSO), has been investigated …

Contraception with RISUG® and functional reversal through DMSO and NaHCO3 in male rabbits

AS Ansari, A Badar, K Balasubramanian… - Asian journal of …, 2017 - journals.lww.com
The study aimed to evaluate reversal of short-and long-term vas occlusion with reversible
inhibition of sperm under guidance (RISUG) using dimethyl sulfoxide (DMSO) and sodium …

RISUG: A new perspective in non–hormonal male contraception

V Thakur, M Choudhary, V Mehta, D Kumar - Asian Pacific Journal of …, 2013 - Elsevier
Currently there are several hormonal and non-hormonal methods of contraception available
but due to long term side effects of hormonal contraceptives, a great research is undergoing …

[PDF][PDF] Development of a nanotechnology based biomedicine RISUG-M as a female contraceptive in India

RK Singh, FW Bansode, S Sharma… - J Nanomed …, 2015 - m.23michael.com
Background and objectives: The aim of this study was to assess the toxic effect of the newly
developed contraceptive RISUG-M in female Charles Foster rats. Methods: Young, healthy …