Aims 5‐hydroxytryptamine3 receptor antagonists act antiemetically and slow colonic transit.
This study evaluated effects of the high‐affinity 5‐HT3 antagonist, cilansetron, on fasting …

Background: Prucalopride is a selective and specific 5‐hydroxytryptamine4 receptor agonist
that is known to increase stool frequency and to accelerate colonic transit. Aim: To …

BACKGROUND Serotonin 5-HT4 receptors are located on enteric cholinergic neurones and
may regulate peristalsis. 5-HT4 receptors on primary afferent neurones have been …

Background & Aims YKP10811, a selective agonist of the serotonin 5-hydroxytryptamine-4
receptor, increases gastrointestinal (GI) motility. We investigated the safety and effects of …

Background It is unclear whether decreased serotonin transporter function contributes to
sensorimotor abnormalities in irritable bowel syndrome. Aim To study the influence of acute …

Summary Background: MKC‐733, a 5‐HT3 receptor partial agonist, is a novel
enteroprokinetic compound. Objective: The aim of this study was to explore the effects of …

1. ICS 205‐930 (Sandoz) is a selective antagonist at 5‐hydroxytryptamine3 receptors and
exerts marked effects on gastrointestinal motility in animals. 2. This study investigated, under …

The newly recognized class of 5-hydroxytryptamine receptors (5HT 3) may be involved in
the induction of nausea, since their pharmacological antagonists are effective against …

Aliment Pharmacol Ther 2010; 32: 289–295 Summary Background Administration of 5‐
hydroxytryptamine (5HT) and selective 5HT receptor ligands modifies interdigestive motility …

Mosapride citrate (mosapride), a substituted benzamide, is a selective 5‐HT4 receptor
agonist, and is known to have prokinetic properties on the stomach. However, it is unclear …