[HTML][HTML] Using experimental models to decipher the effects of acetaminophen and NSAIDs on reproductive development and health
B Boizet-Bonhoure, S Déjardin, M Rossitto… - Frontiers in …, 2022 - frontiersin.org
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid),
diclofenac and ibuprofen (IBU), and analgesic drugs, such as acetaminophen (APAP, or …
diclofenac and ibuprofen (IBU), and analgesic drugs, such as acetaminophen (APAP, or …
Acetaminophen (APAP, paracetamol) interferes with the first trimester human fetal ovary development in an ex vivo model
LL Lecante, S Leverrier-Penna… - The Journal of …, 2022 - academic.oup.com
Context Acetaminophen (APAP, paracetamol) is widely used by pregnant women. Although
long considered safe, growing evidence indicates that APAP is an endocrine disruptor since …
long considered safe, growing evidence indicates that APAP is an endocrine disruptor since …
[HTML][HTML] EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
FS Arendrup, S Mazaud-Guittot, B Jégou… - Endocrine …, 2018 - ec.bioscientifica.com
Concern has been raised over chemical-induced disruption of ovary development during
fetal life resulting in long-lasting consequences only manifesting themselves much later …
fetal life resulting in long-lasting consequences only manifesting themselves much later …
[HTML][HTML] In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice
M Rossitto, M Ollivier, S Déjardin, A Pruvost… - Communications …, 2019 - nature.com
Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesic drugs, such as
acetaminophen (APAP), are frequently taken during pregnancy, even in combination …
acetaminophen (APAP), are frequently taken during pregnancy, even in combination …
Effects of exposure to acetaminophen and ibuprofen on fetal germ cell development in both sexes in rodent and human using multiple experimental systems
P Hurtado-Gonzalez, RA Anderson… - Environmental …, 2018 - ehp.niehs.nih.gov
Background: Analgesic exposure during pregnancy may affect aspects of fetal gonadal
development that are targeted by endocrine disruptors. Objectives: We investigated whether …
development that are targeted by endocrine disruptors. Objectives: We investigated whether …
Acetaminophen and pregnancy: short-and long-term consequences for mother and child
K Thiele, T Kessler, P Arck, A Erhardt… - Journal of reproductive …, 2013 - Elsevier
Counter-intuitively, over-the-counter medication is commonly taken by pregnant women. In
this context, acetaminophen (APAP, eg Paracetamol, Tylenol) is generally recommended by …
this context, acetaminophen (APAP, eg Paracetamol, Tylenol) is generally recommended by …
Intergenerational effects on mouse sperm quality after in utero exposure to acetaminophen and ibuprofen
M Rossitto, C Marchive, A Pruvost, E Sellem… - The FASEB …, 2019 - Wiley Online Library
Nonsteroidal antiinflammatory drugs and analgesic drugs, such as N‐acetyl‐p‐aminophenol
(APAP; acetaminophen, paracetamol), are widely used by pregnant women. Accumulating …
(APAP; acetaminophen, paracetamol), are widely used by pregnant women. Accumulating …
[HTML][HTML] Dysregulation of Immature Sertoli Cell Functions by Exposure to Acetaminophen and Genistein in Rodent Cell Models
M Corpuz-Hilsabeck, N Mohajer, M Culty - Cells, 2023 - mdpi.com
Sertoli cells are essential for germ cell development and function. Their disruption by
endocrine disrupting chemicals (EDCs) or drugs could jeopardize spermatogenesis …
endocrine disrupting chemicals (EDCs) or drugs could jeopardize spermatogenesis …
[HTML][HTML] Potential adverse actions of prenatal exposure of acetaminophen to offspring
K Wu, W Lu, X Yan - Frontiers in Pharmacology, 2023 - frontiersin.org
Acetaminophen (APAP) is a widely used as analgesic and antipyretic drug. APAP is also
added as an active ingredient in various medications to relieve pain and reduce fever. APAP …
added as an active ingredient in various medications to relieve pain and reduce fever. APAP …
Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model
S van den Driesche, J Macdonald… - Science translational …, 2015 - science.org
Most common male reproductive disorders are linked to lower testosterone exposure in fetal
life, although the factors responsible for suppressing fetal testosterone remain largely …
life, although the factors responsible for suppressing fetal testosterone remain largely …