Colorectal carcinoma (CRC) is the second leading cause of cancer-related death in the
United States in the general population (men and women combined). Epidemiologic data …

Aberrant Wnt/β-catenin signaling following loss of the tumor suppressor adenomatous
polyposis coli (APC) is thought to initiate colon adenoma formation. Considerable evidence …

The temporal association between loss of function of the tumor suppressor adenomatous
polyposis coli (APC) and overexpression of cyclooxygenase 2 (COX-2) has been …

Colorectal cancer is a leading cause of cancer-related deaths throughout the world. Non-
steroidal anti-inflammatory drugs (NSAIDs) are among the few agents that are known to …

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

Colorectal cancer is a major cause of mortality and whilst up to 80% of sporadic colorectal
tumours are considered preventable, trends toward increasing obesity suggest the potential …

Colorectal cancer is the second most frequent cancer in the Western world, often lethal
when invasion and/or metastasis occur. In addition to hepatocyte growth factor (HGF), colon …

Prostaglandins induce early growth response 1 transcription factor mediated microsomal
prostaglandin E2 synthase up-regulation for colorectal cancer progression - PMC Back to Top …

The number of colorectal cancer (CRC) patients is increasing worldwide. Accumulating
evidence has shown that the tumor microenvironment (TME), including macrophages …

Colorectal cancer is a relatively common cause of morbidity and mortality in Western
cultures and is perhaps the best characterized form of cancer with respect to the genetic …