Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances α-synuclein fibril formation in vitro

K Ono, M Noguchi-Shinohara, M Yoshita, H Naiki… - Experimental …, 2007 - Elsevier
Deposition of α-synuclein (αS) aggregates inside brain cells is a pathological hallmark of
several neurodegenerative diseases, including Parkinson's disease (PD), and dementia …

Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation

M Hirohata, K Ono, A Morinaga, T Ikeda, M Yamada - Neuroscience letters, 2011 - Elsevier
The aggregation of α-synuclein (αS) in the central nervous system (CNS) is the hallmark of
multiple system atrophy (MSA) and Lewy body diseases including Parkinson's disease (PD) …

[HTML][HTML] Amyloid-beta peptides trigger aggregation of alpha-synuclein in vitro

J Köppen, A Schulze, L Machner, M Wermann… - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) and Parkinson's disease (PD), including dementia with Lewy
bodies (DLB), account for the majority of dementia cases worldwide. Interestingly, a …

[HTML][HTML] Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to …

O Hansson, S Hall, A Öhrfelt, H Zetterberg… - Alzheimer's research & …, 2014 - Springer
Introduction The objective was to study whether α-synuclein oligomers are altered in the
cerebrospinal fluid (CSF) of patients with dementia, including Parkinson disease with …

Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo

T Fagerqvist, T Näsström, E Ihse, V Lindström, C Sahlin… - Amyloid, 2013 - Taylor & Francis
Aggregated α-synuclein is the major component of Lewy bodies, protein inclusions
observed in the brain in neurodegenerative disorders such as Parkinson's disease and …

Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains

J van Horssen, RAI De Vos, ENH Steur… - Journal of …, 2004 - content.iospress.com
Abstract α-Synuclein is the major constituent of Lewy bodies and Lewy neurites in
Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Relatively little is known …

Accumulation of insoluble α-synuclein in dementia with Lewy bodies

BCV Campbell, QX Li, JG Culvenor, P Jäkälä… - Neurobiology of …, 2000 - Elsevier
The α-synuclein (αSN) protein is thought to play a central role in the pathogenesis of
neurodegenerative diseases where it aggregates to form intracellular inclusions. We have …

Effect of α-synuclein on amyloid β-induced toxicity: relevance to Lewy body variant of Alzheimer disease

R Resende, SCF Marques, E Ferreiro, I Simões… - Neurochemical …, 2013 - Springer
Alzheimer's disease, the most prevalent age-related neurodegenerative disease, is
characterized by the presence of extracellular senile plaques composed of amyloid-beta …

α-Synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease β-amyloid plaque cores

TA Bayer, P Jäkälä, T Hartmann, L Havas, C McLean… - Neuroscience …, 1999 - Elsevier
A growing body of evidence suggests that the non-Aβ component of Alzheimer's disease
amyloid precursor protein (NACP) or α-synuclein contributes to the neurodegenerative …

Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies

KE Paleologou, CL Kragh, DMA Mann, SA Salem… - Brain, 2009 - academic.oup.com
A number of neurodegenerative diseases including Parkinson's disease, dementia with
Lewy bodies (DLB) and multiple system atrophy are characterized by the formation and …