The calcium (Ca2+)-sensing receptor (CaR) belongs to family C of the G-protein coupled
receptors (GPCRs). The receptor is activated by physiological levels of Ca2+ (and Mg2+) …

The calcium-sensing receptor (CaR) belongs to the G protein-coupled receptor superfamily,
with a characteristic structure consisting of seven transmembrane helices, an intracellular C …

The extracellular calcium receptor (CaR) is a Family CG protein-coupled receptor that
controls systemic Ca2+ homeostasis, largely by regulating the secretion of parathyroid …

The extracellular calcium receptor (CaR) is a G protein-coupled receptor (GPCR) and the
pivotal molecule regulating systemic Ca 2+ homeostasis. The CaR was a challenging target …

Background and Purpose Clinical use of cinacalcet in hyperparathyroidism is complicated
by its tendency to induce hypocalcaemia, arising partly from activation of calcium‐sensing …

Parathyroid hormone (PTH) secreted from parathyroid cells is a key regulator of circulating
levels of calcium ion, which is maintained within a narrow physiological range mainly by the …

The calcium‐sensing receptor (CaR) is the key controller of extracellular calcium (Ca2+ o)
homeostasis via its regulation of parathyroid hormone (PTH) secretion and renal Ca2+ …

The calcium sensing receptor (CaR) is a G protein-coupled receptor (GPCR) that plays a
fundamental role in serum calcium homeostasis. The CaR is expressed on the chief cells of …

Calcium sensing receptor (CASR) is a G-protein couple receptor which plays a key role in
calcium homeostasis in vertebrates. Its extracellular domain is sensitive to divalent cations …

A hallmark of chronic kidney disease is hyperphosphatemia due to renal phosphate
retention. Prolonged parathyroid gland exposure to hyperphosphatemia leads to secondary …