Cdc48/p97, a ubiquitin-selective chaperone, orchestrates the function of E3 ligases and
deubiquitylases (DUBs). Here, we identify a new function of Cdc48 in ubiquitin-dependent …

Mitochondria continuously undergo coordinated fusion and fission during vegetative growth
to keep their homogeneity and to remove damaged components. A cytosolic AAA ATPase …

Dynamic functionality of mitochondria is maintained by continual fusion and fission events. A
mitochondrial outer membrane protein Fzo1 plays a pivotal role upon mitochondrial fusion …

Mitofusins, conserved dynamin-related GTPases in the mitochondrial outer membrane,
mediate the fusion of mitochondria. Here, we demonstrate that the activity of the mitofusin …

Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …

Mitofusins are dynamin-related GTPases that drive mitochondrial fusion by sequential
events of oligomerization and GTP hydrolysis, followed by their ubiquitylation. Here, we …

Mitochondrial integrity relies on homotypic fusion between adjacent outer membranes,
which is mediated by large GTPases called mitofusins. The regulation of this process …

The mitochondrion is a dynamic membranous network whose morphology is conditioned by
the equilibrium between ongoing fusion and fission of mitochondrial membranes. In the …

Mitochondria are essential organelles whose function is upheld by their dynamic nature.
This plasticity is mediated by large dynamin-related GTPases, called mitofusins in the case …

Mitochondrial morphology depends on balanced fusion and fission events. A central
component of the mitochondrial fusion apparatus is the conserved GTPase Fzo1 in the outer …