[HTML][HTML] Recent updates on induced pluripotent stem cells in hematological disorders

M Wattanapanitch - Stem cells international, 2019 - hindawi.com
Over the past decade, enormous progress has been made in the field of induced pluripotent
stem cells (iPSCs). Patients' somatic cells such as skin fibroblasts or blood cells can be used …

Application of induced pluripotent stem cell technology to the study of hematological diseases

M Li, P Cascino, S Ummarino, A Di Ruscio - Cells, 2017 - mdpi.com
The burst of reprogramming technology in recent years has revolutionized the field of stem
cell biology, offering new opportunities for personalized, regenerative therapies. The direct …

Application of induced pluripotent stem cells to hematologic disease

PG Kim, GQ Daley - Cytotherapy, 2009 - Elsevier
Induced pluripotent stem cells (iPSC) were first generated from somatic cells via the
transduction of four 'Yamanaka'factors, Oct4, Sox2, Klf4 and c-Myc. Because iPSC are …

Pluripotent stem cells and gene therapy

P Simara, JA Motl, DS Kaufman - Translational research, 2013 - Elsevier
Human pluripotent stem cells represent an accessible cell source for novel cell-based
clinical research and therapies. With the realization of induced pluripotent stem cells …

Induced pluripotent stem cells as a tool for modeling hematologic disorders and as a potential source for cell-based therapies

P Pratumkaew, S Issaragrisil, S Luanpitpong - Cells, 2021 - mdpi.com
The breakthrough in human induced pluripotent stem cells (hiPSCs) has revolutionized the
field of biomedical and pharmaceutical research and opened up vast opportunities for drug …

Ten years of iPSC: clinical potential and advances in vitro hematopoietic differentiation

BCMF Paes, PD Moço, CG Pereira, GS Porto… - Cell biology and …, 2017 - Springer
Ten years have passed since the first publication announcing the generation of induced
pluripotent stem cells (iPSCs). Issues related to ethics, immune rejection, and cell availability …

Evolution of induced pluripotent stem cell technology

H Zhou, S Ding - Current opinion in hematology, 2010 - journals.lww.com
Summary iPSC technology provides unprecedented opportunities in biomedical research
and regenerative medicine. However, there remain a great deal to learn about iPSC safety …

Hematopoietic stem cells from pluripotent stem cells: Clinical potential, challenges, and future perspectives

S Demirci, A Leonard, JF Tisdale - Stem cells translational …, 2020 - academic.oup.com
The generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells
(iPSCs) is an active and promising area of research; however, generating engraftable HSCs …

Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood Cells—Ready for Take-Off

K Haake, M Ackermann… - Stem cells translational …, 2019 - academic.oup.com
Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have opened up a
world of possibilities for regenerative medicine and novel cell-based therapeutics. Now, over …

Induced pluripotent stem cells in hematology: current and future applications

D Focosi, G Amabile, A Di Ruscio, P Quaranta… - Blood cancer …, 2014 - nature.com
Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays
approaching effectiveness and clinical grade. Potential uses of this technology include …