OBJECTIVE: The aim of this study was to analyze autonomic function and cardiac
sympathetic innervation in symptomatic and asymptomatic carriers of the E46K alpha …

Introduction Here we report the case of an asymptomatic carrier of the E46K substitution in α-
synuclein gene where we have documented that cardiac sympathetic denervation precedes …

Parkinson's disease patients frequently have symptoms and signs of autonomic nervous
dysfunction that are the source of considerable disability. Recent studies have revealed that …

Introduction Parkinson disease (PD), pure autonomic failure (PAF), and multiple system
atrophy (MSA) are characterized by intra-cerebral deposition of the protein alpha-synuclein …

Objective Lewy body (LB) synucleinopathies such as Parkinson's disease (PD) entail
profound cardiac norepinephrine deficiency. The status of sympathetic noradrenergic …

Background Autonomic synucleinopathies feature deposition of the protein alpha-synuclein
(AS) in neurons [eg, Lewy body neurogenic orthostatic hypotension (nOH)] or glial cells …

Cardiovascular autonomic failure is the second most common dysautonomic feature of α‐
synucleinopathies and has significant impact on daily activities and quality of life. Here we …

Differentiating multiple system atrophy (MSA) from Parkinson disease with orthostatic
hypotension (PD+ OH) can be very difficult clinically. All patients with PD+ OH have …

Pure autonomic failure (PAF), a rare clinical manifestation of Lewy body (LB) disorders, is
characterized by fibrillary aggregates of α-synuclein in the cytoplasm of a select population …

Pathological aggregates of alpha-synuclein in peripheral dermal nerve fibers can be
detected in patients with idiopathic Parkinson's disease and multiple system atrophy. This …