Exposure of rats to hypoxia (7% O 2) markedly increased the level of heme oxygenase-1
(HO-1) mRNA in several tissues. Accumulation of HO-1 transcripts was also observed after …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that is critical for
hypoxic induction of a number of physiologically important genes. We present evidence that …

Using hyperoxia as a model of oxidant-induced lung injury in the rat, we explored the
regulation of heme oxygenase-1 (HO-1) expression in vivo and in vitro. We demonstrate …

We have shown previously that activation of the heme oxygenase-1 (ho-1) gene by hypoxia
in aortic smooth muscle cells is mediated by hypoxia-inducible factor-1 (HIF-1). In mutant …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription
factor that regulates genes whose products play key roles in maintaining O2homeostasis …

HIF (hypoxia-inducible factor)-3α is the third member of the HIF transcription factor family.
Whereas HIF-1α and-2α play critical roles in the cellular and systemic adaptation to hypoxia …

Hypoxia-inducible expression has been demonstrated for many groups of mammalian
genes, and studies of transcriptional control have revealed the existence of hypoxia …

Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin
(Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatment …

Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …

The hypoxia-inducible factors 1α (HIF-1α) and 2α (HIF-2α) have extensive structural
homology and have been identified as key transcription factors responsible for gene …