Abstract Spinal Cord Injury (SCI) is one of the leading causes of physical disability. In this
study, spherical PLGA nanoparticles (NPs) containing ChABC enzyme were manufactured …

New treatment strategies for spinal cord injury with good therapeutic efficacy are actively
pursued. Here, acetalated dextran (AcDX), a biodegradable polymer obtained by modifying …

As a worldwide medical problem, spinal cord injury has no clear and effective treatment to
improve its prognosis. Hence, new treatment strategies for spinal cord injury with good …

The cell-cycle inhibitor flavopiridol has been shown to improve recovery from spinal cord
injury in animal models. However, the systemic dose of flavopiridol has side-effects and the …

Background Currently, combined therapies could help to reduce long-term sequelae of
spinal cord injury (SCI); stem cell therapy at the site of injury in combination with other …

Objectives: Biomaterials are used to aid in the regeneration of damaged tissue and in
promotion of axonal guidance following spinal cord injury (SCI). In the present study …

In spinal cord injuries, axonal regeneration decreases with the activation of astrocytes
followed by glial scar formation. Targeting reactive astrocytes has been recently performed …

Hydrogels have been increasingly applied in tissue regeneration and drug delivery systems
(DDS). In this study, the capacity of valproic acid (Val) encapsulated within hybrid of alginate …

To modify surface of resveratrol using nanotechnology that may ensure optimum drug
availability at the spinal cord injury site and reduce its dosing frequency. Chitosan coated …

Introduction After traumatic spinal cord injury (SCI), an inhibitory environment that contains
chondroitin sulfate proteoglycans (CSPGs) is formed that prevents axonal regeneration and …