Highlights•COX-2 is overexpressed in tumour cells and is involved in cell proliferation and
progression and angiogenesis.•COX-2 inhibitors can block various signalling pathways …

Cyclooxygenase-2 (COX-2) is an enzyme expressed primarily in pathologic states, such as
inflammatory disorders and cancer, where it mediates prostaglandin production. Its …

The development of new chemotherapeutic agents and concepts of radiation therapy has
led to new perspectives in cancer therapy. Recently developed novel agents interfere with …

Cyclooxygenase-2 (COX-2) is an enzyme induced by a variety of factors including tumor
promoters, cytokines, growth factors and hypoxia. It is involved in the metabolic conversion …

Background: Each year, millions of people die from cancer. Radiotherapy is one of the main
treatment strategies for cancer patients. Despite the beneficial roles of treatment with …

Abstract Cyclooxygenase-2 (COX-2), an enzyme induced by proinflammatory cytokines,
mitogenic substances, oncogenes, growth factors, and hypoxia, among others, is involved in …

Results of preclinical studies suggesting that the efficacy of molecular therapies is enhanced
when they are combined with radiation have generated a surge of clinical trials combining …

Since cyclooxygenase-2 (COX-2) is overexpressed in malignant tissues, the COX-2
mediated signaling pathway has been recognized as potential target for therapeutic …

Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …

Radiation therapy has traditionally been the treatment of choice for locally or regionally
advanced cancer, but its therapeutic efficacy is often hindered by limited tolerance of normal …