Quantitative analysis of electroencephalography (EEG) is used increasingly to evaluate the
pharmacodynamics of benzodiazepines. The present study aimed to apply the EEG method …

Background and objectives Benzodiazepine agonists and azaperone derivatives are used
clinically as anxiolytics but have different neuroreceptor mechanisms of action. This study …

Objective We assessed the effect of voriconazole and fluconazole on the pharmacokinetics
and pharmacodynamics of diazepam. Methods Twelve healthy volunteers took 5 mg of oral …

Single dose pharmacokinetics of oxazepam, 30 mg, have been studied in six healthy male
volunteers in the absence of diflunisal and during continuous treatment with diflunisal 500 …

Eleven healthy subjects received single oral doses of placebo, 2 mg diazepam, 5 mg
diazepam, and 10 mg diazepam in a randomized four‐way crossover study. Plasma …

The aim of this study was to see if the immediate EEG and clinical response to an
intravenous dose of clonazepam was predictive for the effect of oral clonazepam …

Blood levels and electroencephalographic (EEG) data were collected for 2 hr after single
oral doses of bromazepam (9 mg), diazepam (10 mg), and placebo in 13 male adult …

Rationale and objective Bromazepam, an anti-anxiety agent, has been reported to be
metabolized by cytochrome P 450 (CYP). However, the enzyme responsible for the …

Biopharmaceutical and clinical pharmacokinetic profile of bromazepam Page 1 Journal of
Pharmacokinetics and Biopharmaceutics, Vol. 4, No. 1, 1976 Biopharmaceutical and Clinical …

A new formulation of oxazepam especially designed to increase the speed of absorption
and eliminate the need to use water (freeze-dried dosage formulation; FDDF) was compared …