Abstract Background P21-activated kinase 1 (PAK1) stimulates growth and metastasis of
colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of …

The p21-activated kinase 1 (PAK1) plays important roles in cell growth, motility, and
transformation. The aims of this study were to delineate the signalling mechanisms …

The p21 activated kinases (PAKs) are known to play a role in the regulation of cell
morphology and functions. Among the various members of PAKs family, only the PAK4 …

Background P21-activated kinases (PAKs) are small guanosine triphosphate effectors that
play critical roles in many fundamental cellular functions, including cytoskeletal …

Abstract p21-activated kinase 1 (PAK1) is a serine/threonine kinase that is overexpressed in
colorectal cancer. PAK1 is a target of mesalamine [5-aminosylicylic acid (5-ASA)], a common …

Abstract P21 activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by
stimulating Wnt/β-catenin and Ras oncogene, which promote CRC survival via stimulation of …

Abstract P21‐activated kinase 5 (PAK5) is the recently identified member of the group B p21‐
activated kinase (PAK) family which are effectors of the small GTPase Cdc42 and Rac1 …

Background Chronic gut inflammation predisposes to the development of colorectal cancer
and increased mortality. Use of mesalamine (5-ASA) in the treatment of ulcerative colitis …

Abstract P21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases with
both kinase and scaffolding activity. Here, we investigated the effects of inflammation on …

Cancer stem cells (CSC) are tumorigenic and resistant to chemotherapy. In colorectal
cancer (CRC), CSCs have been identified by the expression of specific markers, including …